Relationships between Transforming Growth Factor-β1, Myostatin, and Decorin
نویسندگان
چکیده
منابع مشابه
Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis.
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملRelationships between Tgf-β1, Myostatin, and Decorin: Implications for Skeletal Muscle Fibrosis*
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملTransforming Growth Factor-β Signaling by Decorin
3 Chen Zhang, Chek Kun Tan, Craig McFarlane, Mridula Sharma, Nguan Soon Tan*, Ravi 4 Kambadur,*# 5 1. School of Biological Sciences, Nanyang Technological University, Singapore 637551. 6 2 Singapore Institute for Clinical Sciences, A*STAR, 30 Medical Centre Drive, National 7 University of Singapore, Singapore 8 3 Department of Biochemistry, YLL School of Medicine, National University of 9 Singa...
متن کاملGranzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1
OBJECTIVE Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-mediated target cell apoptosis. However, during inflammation, GrB accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular matrix (ECM) proteins. Recent studies have implicated a pathogenic extracellular role for GrB in cardiovascular disease, yet the pathophysi...
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Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-β1 has been demon...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m704146200